Glutamate–cysteine Ligase

Glutamate Cysteine Ligase, previously known as gamma-glutamylcysteine synthetase, is the first enzyme of the cellular glutathione biosynthetic pathway that catalyzes the chemical reaction: L-glutamate + L-cysteine + ATP gamma-glutamyl cysteine + ADP + Pᵢ GSH, and by extension GCL, is critical to cell survival.