Vascular Dementia
| Use attributes for filter ! | |
| Google books | books.google.com |
|---|---|
| Originally published | January 17, 2001 |
| Editors | Gaiane Rauch |
| Helmut Lechner | |
| Carlo Loeb | |
| Date of Reg. | |
| Date of Upd. | |
| ID | 2109164 |
About Vascular Dementia
Vascular dementia (VAD) accounts for one-third of all dementias in today''s aging population, second only to Alzheimer's disease (DAT). . . .
Prunella Scales and Timothy West: Dementia won't break our 60-year love affair
... " The book may mainly focus on the fun, but it does not shy away from discussing the Vascular Dementia, which Scales has had for the more than 20 years - over a third of their married life...
Shared appreciation mortgages: The 1990s deals that became a nightmare
... Margaret, who has Vascular Dementia, had to move into a care home...
Jean Boht: Bread actress dies at 91
... " The statement added: " Jean had been battling Vascular Dementia and Alzheimer s disease with the indefatigable spirit for which she was both beloved and renowned...
Alastair Stewart: Retired news presenter reveals dementia diagnosis
... He explained to former colleague Camilla Tominey he had been diagnosed with early onset Vascular Dementia...
Drug donanemab seen as turning point in dementia fight
... It works in Alzheimer s disease, not in other types of dementia, such as Vascular Dementia...
Fiona Phillips: How common is early Alzheimer's?
... Others include Vascular Dementia, dementia with Lewy bodies, fronto-temporal dementia, Parkinson s disease dementia, amyotrophic lateral sclerosis and the newly discovered Late...
Unpaid carers: 'I had to choose to care for my husband or my sister'
... Ian, who was an engineer as well as a keen cyclist and photographer, was diagnosed with Vascular Dementia in 2020 while Jennifer is living with young onset Alzheimer s disease...
'I wouldn't bring a member of my family to this hospital,' says medic
... In late April, Edna Wilson, 86, called 999 for her long-term companion Steve Winfield, 70, who had Vascular Dementia...
Drug donanemab seen as turning point in dementia fight
By Fergus Walsh and Michelle RobertsBBC News
Results out today confirm that the drug donanemab, hailed as a Turning Point in The Fight against Alzheimer's, slows cognitive decline by about a third.
Mike Colley, who is 80, is one of only a few dozen patients in the UK to take part in the global trial, now published in the journal.
He gets an infusion each month at a clinic in London and says he is " one of the luckiest people you'll ever meet".
The antibody treatment helps in the early stages of the Disease .
It works in Alzheimer's Disease , not in other types of dementia, such as Vascular Dementia .
That is because it is designed to clear away one of The Key features of Alzheimer's Disease - a substance called amyloid that builds up in the spaces between brain cells.
Mike and His Family noticed he was having problems with memory and decision-making, not long before he started on The Trial .
His son, Mark, said it was very hard to watch at The Beginning : " Seeing him struggle with processing information and solving problems was very hard. But I think The Decline is reaching a plateau now. "
Speaking exclusively to The Bbc , Mike, who is from Kent, said: " I feel more confident Every Day . "
Donanemab, made by Eli Lilly , works in the same way as lecanemab - developed by companies Eisai and Biogen - When it was proven to slow the Disease .
Although extremely promising, these drugs are not cures or risk-free treatments.
Brain swelling was a common side-effect in up to a third of patients in the donanemab trial. For most, this resolved without causing symptoms. However, two volunteers, and possibly a third, died as a result of dangerous swelling in The Brain .
Another antibody Alzheimer's drug, called aducanumab, was recently over safety concerns and a lack of evidence that it was effective enough for patients.
What is dementia and what can be done about it?In the donanemab trial, researchers examined 1,736 people aged 60 to 85 with early-stage Alzheimer's.
Half of them received a monthly infusion of The Treatment and The Other half were given a dummy drug, also known as a placebo, over 18 Months .
The findings show:
Amyloid is just one part of The Complex picture of Alzheimer's, and it is unclear if The Treatment will continue to make more difference over a longer period, experts caution.
The drug's effects may be modest, but the results provide further confirmation that removing amyloid from The Brain may change The Course of Alzheimer's, and help people affected by this devastating Disease if they're treated at The Right time, they say.
Prof Giles Hardingham from the UK Dementia Research Institute , said: " It is terrific to see these results published in full today. We have waited a long time for Alzheimer's treatments, so it's really encouraging to see tangible progress continuing to gather pace in The Field . We're on The Edge of exciting and significant change in the landscape of treatment for people affected by - or At Risk of -dementia. "
Dr Susan Kohlhaas, from Alzheimer's Research UK, said: " Today's announcement marks another milestone. Thanks to decades of research, the outlook for dementia and its impact on people and society is finally changing, and we're entering a new era where Alzheimer's Disease could become treatable. "
Mike Colley turned 80 in April. At his birthday party, he surprised His Family by singing My Way in front of 40 guests.
He told Bbc News : " That's the confidence I have now. I'd never have done that even 12 Months ago. "
His son Mark added: " I never thought I would see my dad so full of life again. It was an incredible moment. "
Dr Emer MacSweeney, consultant neuroradiologist and medical director at Re: Cognition Health, led the trials of donanemab in the UK.
She Said : " This is really significant And One of the biggest breakthroughs. "
The Alzheimer's Society said: " This is truly a Turning Point in The Fight against Alzheimer's and science is proving that it is possible to slow down the Disease . "
Around 720,000 people in the UK might potentially benefit from these emerging new Alzheimer's Disease treatments if they're approved for use, but the Alzheimer's Society said the NHS is " simply not ready to deliver them".
Kate Lee, a spokeswoman for The Charity , said: " Timely, accurate diagnosis is key, and currently only 2% of people in England and Wales receive their diagnosis through The Specialist investigations needed to be eligible for these treatments.
" Alongside this, these emerging Alzheimer's Disease drugs require regular infusions and monitoring, and the NHS is Not Yet equipped to do this at scale. "
Lecanemab costs around $27,500 (£21,000) in the US, where it is licensed.
It is not clear how much Donanemab may cost and how long it might take to get approval in the UK, but Alzheimer's experts said having two drugs would help promote competition on price.
The UK's drug's watchdog NICE says it has already started work on its appraisal of donanemab for treating mild cognitive impairment or mild dementia caused by Alzheimer's Disease .
" Our aim is to produce recommendations on its use in the NHS as close as possible to it receiving its UK licence, " said a spokesperson.
Related TopicsSource of news: bbc.com