Steven Rosenberg

Steven Rosenberg

American surgeon



  • Photos
    Steven Rosenberg - American surgeon
Steven Rosenberg Profiles
social profile link xwhos social profile link Google Scholar social profile link Instagram social profile link LinkedIn social profile link Twitter
  • About

    Steven A. Rosenberg is an American cancer researcher and surgeon, chief of Surgery at the National Cancer Institute in Bethesda, Maryland and a Professor of Surgery at the Uniformed Services University of Health Sciences and the George Washington University School of Medicine and Health Sciences.

    Related searches

    steven rosenberg nobel prize, steven rosenberg car t, steven rosenberg wife, steven rosenberg linkedin, steven rosenberg til, steven rosenberg lawyer, steven rosenberg math, steven rosenberg, dds,
    Detail from wiki

    Steven A. Rosenberg (born 2 August 1940) is an American cancer researcher and surgeon, chief of Surgery at the National Cancer Institute in Bethesda, Maryland and a Professor of Surgery at the Uniformed Services University of Health Sciences and the George Washington University School of Medicine and Health Sciences. He pioneered the development of immunotherapy that has resulted in the first effective immunotherapies and the development of gene therapy. He is the first researcher to successfully insert foreign genes into humans.

    Early life


    Rosenberg was born in 1940, in the Bronx, the youngest of three children of Jewish immigrants from Poland, who owned a luncheonette. He met his wife to be, Alice O’Connell during his residency at Boston’s Peter Bent Brigham Hospital, who was the chief nurse at the time. They got married in 1968 and have three daughters.

    Methodology


    He is accredited with developing the use of IL-2 and immune cells for the treatment of patients with melanoma in a procedure termed adoptive cell transfer. He has shown that expanding immune cells (known as tumor infiltrating lymphocytes) in the lab can be used to treat patients with melanoma and has published two important studies describing their use. The first in 2002, demonstrated that some patients with advanced melanoma can be treated to complete remission with a combination of chemotherapy, immune cells and high doses of IL-2. The second, in 2006, demonstrated that the receptor of T cells can be transferred to immune cells and in combination with chemotherapy and high doses of IL-2 can be used to treat patients with melanoma. Although, this was the first time that the T cell receptor was used for gene therapy, it was not the first time that gene therapy was used in cancer. Tumor cells modified with a gene for immune growth factors such as GM-CSF, had been used many years previously and continue to be used, although the efficacy of GM-CSF modified tumor lines as a cancer vaccine remain extremely modest, at best. There has been some debate as to the role of the T cells in treating the cancer in these studies as high-dose IL-2 and chemotherapy have also been shown to have anti-cancer properties. Nevertheless, the combination of chemotherapy, T cells and high-dose IL-2 was shown to be effective even in patients who had previously failed high-dose IL-2 treatment.

    Rosenberg has pioneered the use of adoptive immunotherapy.

    Education


    Rosenberg graduated from the Bronx High School of Science. He received his B.A. (biology, 1961) and M.D. (1964) degrees from The Johns Hopkins University. He served a surgical internship and residency at the Peter Bent Brigham Hospital, completing it in 1974. During his residency he also earned a Ph.D. in biophysics from Harvard University with thesis titled The proteins of human erythrocyte membranes (in 1968/1969). Following the completion of his surgical residency, he became the Chief of Surgery at the National Cancer Institute a position he continues to hold. His research has focused on the immunotherapy of cancer.

    Awards and honors


    1992 Golden Plate Award of the American Academy of Achievement

    2011 William B. Coley Award for Distinguished Research in Tumor Immunology of the Cancer Research Institute

    2013 Keio Medical Science Prize

    2015 Medal of Honor of the American Cancer Society

    2018 Albany Medical Center Prize in Medicine and Biomedical Research

    2019 Edogawa NICHE Prize

    2019 Szent-Györgyi Prize for Progress in Cancer Research

    2021 Dan David Prize

    See also


    Cell therapy

    Chimeric antigen receptor

    Immunotherapy

    Iovance Biotherapeutics

    External links


    Gene therapy rids men of cancer, BBC News (2006 coverage of cancer breakthrough discovered by his team)

    "Cancer Miracles", Robert Langreth, Forbes, 2009

  • Photos
    Steven Rosenberg - American surgeon
© 2015 xwhos.com
About us Help