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Initial release USA
Directors Andrew Bujalski
Box office104,507 USD
Screenplay Andrew Bujalski
Composers Justin Rice
Date of Reg.
Date of Upd.
ID2315081
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About Results


A wealthy, but miserable, slob tries to improve his life and soon becomes inextricably entangled with a self-styled guru/gym owner and acerbic personal trainer.

Macallan: Rare Scotch whisky becomes world's most expensive bottle at £2. 1m

Macallan: Rare Scotch whisky becomes world's most expensive bottle at £2. 1m
Nov 18,2023 9:31 pm

... And whenever any of the bottles have been auctioned over the years there have been extraordinary Results - a similar bottle was sold in 2019 for £1...

GCSE results set to drop close to pre-Covid levels

GCSE results set to drop close to pre-Covid levels
Aug 23,2023 6:00 pm

...By Hazel ShearingEducation correspondentGCSE Results in England are set to drop for a second year running, bringing grades back in line with 2019 levels...

I felt lost after school exam results, now I run a £5m firm

I felt lost after school exam results, now I run a £5m firm
Aug 17,2023 11:41 am

...By Nathan Standley & Kristian JohnsonBBC NewsIf your exam Results do not go the way you want them to, there is still hope for a bright future...

Fewer BTec pupils to face results delays this year, Ofqual says

Fewer BTec pupils to face results delays this year, Ofqual says
Aug 4,2023 5:51 am

...By Alice EvansBBC NewsFewer students taking vocational qualifications are expected to face delays to their Results this year, England s exams regulator Ofqual says...

Housebuilder sees rise in 36-year mortgages

Housebuilder sees rise in 36-year mortgages
Aug 2,2023 9:30 am

... It added that the " substantially higher mortgage rates" had " inevitably" hit its Results - but it said it expected to sell between 10,000 and 10,500 homes by the end of the year, which was at the upper end of its expectations...

Adenomyosis: NHS failing women, health ambassador says

Adenomyosis: NHS failing women, health ambassador says
Jun 6,2023 1:20 pm

... " Delivering Results An NHS official said: " The NHS takes women s health very seriously and, in line with [National Institute for Health and Care Excellence] guidance, we provide a wide range of treatments and support for many conditions, including adenomyosis...

New superbug-killing antibiotic discovered using AI

New superbug-killing antibiotic discovered using AI
May 25,2023 11:10 am

... The Results - - showed it took the AI an hour and a half to produce a shortlist...

A-levels, T-levels and BTecs: A guide to the 2023 exams

A-levels, T-levels and BTecs: A guide to the 2023 exams
May 13,2023 3:30 am

... Are exams and Results still different because of Covid? As usual, senior examiners will decide the minimum marks needed for each grade...

New superbug-killing antibiotic discovered using AI

May 12,2023 8:41 pm

By James GallagherHealth and science correspondent

Scientists have used Artificial Intelligence (AI) to discover a new antibiotic that can kill a Deadly Species of superbug.

The AI helped narrow down thousands of potential chemicals to a handful that could be tested in The Laboratory .

The result was a potent, experimental antibiotic called abaucin, which will need further tests before being used.

The researchers in Canada and the US say AI has The Power to massively accelerate The Discovery of new drugs.

It is the latest example of how the tools of Artificial Intelligence can be a revolutionary force in science and medicine.

Stopping the superbugs

Antibiotics kill Bacteria . However, there has been a lack of new drugs for decades and Bacteria are becoming harder to treat, as they evolve resistance to the ones we have.

are estimated to die from infections that resist treatment with antibiotics.

The researchers focused on one of The Most problematic species of Bacteria - which can infect wounds and cause pneumonia.

You may not have heard of it, but it is one of the three superbugs The World Health Organization has identified as.

It is often able to shrug off multiple antibiotics and is a problem in hospitals and care homes, where it can survive on surfaces and medical equipment.

Dr Jonathan Stokes , from Mcmaster University , describes The Bug as " Public Enemy number one" as it's " really common" to find cases where it is " resistant to nearly every antibiotic".

Artificial Intelligence

To find a new antibiotic, the researchers first had to train the AI. They took thousands of drugs where the precise chemical structure was known, and manually tested them on to see which could slow it down or Kill It .

This information was fed into the AI so it could learn the chemical features of drugs that could attack the problematic bacterium.

The AI was then unleashed on a list of 6,680 compounds whose effectiveness was unknown. The Results - - showed it took the AI an hour and a half to produce a shortlist.

The researchers tested 240 in The Laboratory , and found nine potential antibiotics. One of them was the incredibly potent antibiotic abaucin.

Laboratory experiments showed it could treat infected wounds in mice and was able to kill samples from patients.

However, Dr Stokes told me: " This is when The Work starts. "

The Next step is to perfect the drug in The Laboratory And Then perform clinical trials. He expects The First AI antibiotics could take until 2030 until they are available to be prescribed.

Curiously, this experimental antibiotic had no effect on other species of Bacteria , and works only on.

Many antibiotics kill Bacteria indiscriminately. The researchers believe the precision of abaucin will make it harder for drug-resistance to emerge, and could lead to fewer side-effects.

In principle, the AI could screen tens of millions of potential compounds - Something that would be impractical to do manually.

" AI enhances the rate, and in a Perfect World decreases the cost, with which we can discover these new classes of antibiotic that we desperately need, " Dr Stokes told me.

The researchers tested the principles of AI-aided antibiotic discovery, but have now used that knowledge to Focus On the big nasties. They plan to look at and next.

" This finding further supports the premise that AI can significantly accelerate and expand our search for novel antibiotics, " said Prof James Collins , from the Massachusetts Institute of Technology.

He added: " I'm excited that this work shows that we can use AI to help combat problematic pathogens such as A. baumannii. "



Source of news: bbc.com

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