Red Blood
| Use attributes for filter ! | |
| Google books | books.google.com |
|---|---|
| Originally published | 1997 |
| Authors | Jack D. Forbes |
| Genres | Bildungsroman |
| Political Fiction | |
| Date of Reg. | |
| Date of Upd. | |
| ID | 2400818 |
About Red Blood
"Red Blood traces part of the life's journey of Jesse Rainwater, a young Native American man, as he travels throughout North America and Mexico. Jesse interacts with a variety of other people, and gains valuable insight into his own values, relationships, spirituality, heritage, and self-discovery. . . .
Casgevy: UK approves gene-editing drug for blood disorders
... People with sickle cell disease produce unusually shaped Red Blood cells that can cause problems because they do not live as long as healthy blood cells and can block blood vessels, causing pain and life-threatening infections...
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... As a second badly wounded soldier pulls himself up onto the relative safety of a nearby armoured personnel carrier - arms flailing like a swimmer trying to cling onto a lifeboat - as a thick smudge of dark Red Blood marks his agonising progress...
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... It causes Red Blood cells to distort and become sticky, blocking vessels and restricting oxygen supply, which triggers excruciating pain...
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... The MCV, or " Mean Corpuscular Volume" count, measures the average size of Red Blood cells, which are responsible for transporting oxygen from the lungs to other parts of the body...
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... The condition, which affects Red Blood cells, means people must keep warm to avoid painful flare-ups which can often lead to a hospital stay...
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... " They somehow pack most of the Red Blood cells in the liver, so they re removed from the blood plasma...
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... The double-walled organ is composed of nerves, collagen and Red Blood cells consistent with erectile tissue, Ms Folwell said she started looking for it because the literature she had read about snake s female sexual organs - that they didn t have them or had been bred out through evolution - " just didn t quite sit right with me, " she said...
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... It focuses on the Red Blood cells that carry oxygen from the lungs to the rest of the body...
Casgevy: UK approves gene-editing drug for blood disorders
By Fergus WalshMedical editor
In a world first, medical regulators in the UK have approved a gene therapy That aims to cure two blood disorders.
The Treatment for sickle cell disease and beta thalassemia is The First to be licensed using the gene-editing tool known as Crispr, for which its
This is a revolutionary advance for two inherited blood conditions, both triggered by errors in the gene for haemoglobin.
People with sickle cell disease produce unusually shaped Red Blood cells That can cause problems because they do not live as long as healthy blood cells and can block blood vessels, causing pain and Life -threatening infections.
People with beta thalassaemia do not produce enough haemoglobin, which is used by Red Blood cells to carry oxygen around The Body . Patients with beta thalassemia often need a Blood Transfusion every few weeks of their lives.
How it works
DNA is The Blueprint of Life - and genes contain the instructions for how every cell in Our Body works.
Gene-editing allows the precise manipulation of DNA. The Treatment involves removing stem cells from a patient's bone marrow.
In a laboratory, the gene-editing tool Crispr uses molecular scissors to make precise cuts in the DNA of the cells, thus disabling the faulty gene. The modified cells are infused back, allowing The Body to start producing functioning haemoglobin.
In trials, 28 out of 29 sickle cell patients were free of severe pain and 39 of 42 beta thalassemia patients no longer needed blood transfusions for at least a year. It's hoped it could be a permanent fix.
Trials are continuing in the UK, US, France, Germany and Italy.
Around 15,000 people in the UK have sickle cell disorder, most with an African or Caribbean family background. More Than 1,000 people in the UK are affected by thalassemia, mainly those of Mediterranean, southeast Asian and Middle Eastern origin.
" Both sickle cell disease and beta thalassemia are painful, Life -long conditions That in some cases can be fatal, " said Julian Beach, interim Executive Director of healthcare quality and access at the Medicines and Healthcare products Regulatory Agency (MHRA).
" To date, a bone marrow transplant - which must come from a closely matched donor and carries a risk of Rejection - has been the only permanent treatment option. "
But now a " first-of-its-kind" gene-editing treatment called Casgevy has been authorised by the MHRA, He Said .
In trials, it has been " found to restore healthy haemoglobin production in the majority of participants with sickle-cell disease and transfusion-dependent beta thalassaemia, relieving the symptoms of disease" He Said .
John James OBE, Chief Executive of the Sickle Cell Society said: " Sickle cell disorder is an incredibly debilitating condition, causing significant pain for The People who live it and potentially leading to early mortality.
" There are limited medicines currently available to patients, so I welcome today's news That a new treatment has been judged safe and effective, which has the potential to significantly improve the quality of Life for so many. "
No price has yet been set for Casgevy, but The One off treatment might cost £1 million or More - which could be deemed too high a price for the NHS to bear.
In April, a US Think Tank , ICER,
For Casgevy, the drug is a personalised one-off treatment made from tweaking the patient's own cells - That makes it expensive and time-consuming. Add in the cost of research and development - There are just two labs one in the US and The Other in the UK - currently producing the drug.
The Boston-based pharma company involved, Vertex, will want its product used as widely as possible so will need to set a price That health services here and abroad are prepared to pay.
Related TopicsSource of news: bbc.com