Our Body
| Use attributes for filter ! | |
| Initial release | South Korea |
|---|---|
| Directors | Han Ka-ram |
| Screenplay | Han Ka-ram |
| Composers | Lee Soo-yeon |
| Lee Hae-in | |
| Producers | Seok-geun Oh |
| Park Syu-young | |
| Date of Reg. | |
| Date of Upd. | |
| ID | 2125202 |
About Our Body
Our Body is a 2018 South Korean drama film written, directed and edited by Han Ka-ram.
Casgevy: UK approves gene-editing drug for blood disorders
... How it worksDNA is the blueprint of life - and genes contain the instructions for how every cell in Our Body works...
Why do we itch when reading about bedbugs?
... " If we are scared, anxious, or grossed out by something, Our Body goes on high alert to detect that potential threat ...
How often should you wash and change your towel?
... When we dry the different areas of Our Body, they pick up organisms - such as on our feet like the one that causes athlete s foot...
Heatwave: How hot is too hot for the human body?
... " You will be sweating and yOur Body s physiology is going to change quite considerably, " Prof Bailey warns me...
Million-year-old viruses help fight cancer, say scientists
... B-cells are the part of Our Body that manufactures antibodies and are better known for their role in fighting off infections, such as Covid...
Could a fungal pandemic turn us all into zombies?
... " Our Body temperature is simply too high for most fungi to nicely settle and grow - and this is the same for this Cordyceps...
Base editing: Revolutionary therapy clears girl's incurable cancer
... Just as letters in the alphabet spell out words that carry meaning, the billions of bases in our DNA spell out the instruction manual for Our Body...
Have I dodged Covid and what does it mean?
... This stops them infecting Our Body s cells and tells the rest of the immune system to kill the virus...
Casgevy: UK approves gene-editing drug for blood disorders
By Fergus WalshMedical editor
In a world first, medical regulators in the UK have approved a gene therapy That aims to cure two blood disorders.
The Treatment for sickle cell disease and beta thalassemia is The First to be licensed using the gene-editing tool known as Crispr, for which its
This is a revolutionary advance for two inherited blood conditions, both triggered by errors in the gene for haemoglobin.
People with sickle cell disease produce unusually shaped Red Blood cells That can cause problems because they do not live as long as healthy blood cells and can block blood vessels, causing pain and Life -threatening infections.
People with beta thalassaemia do not produce enough haemoglobin, which is used by Red Blood cells to carry oxygen around The Body . Patients with beta thalassemia often need a Blood Transfusion every few weeks of their lives.
How it works
DNA is The Blueprint of Life - and genes contain the instructions for how every cell in Our Body works.
Gene-editing allows the precise manipulation of DNA. The Treatment involves removing stem cells from a patient's bone marrow.
In a laboratory, the gene-editing tool Crispr uses molecular scissors to make precise cuts in the DNA of the cells, thus disabling the faulty gene. The modified cells are infused back, allowing The Body to start producing functioning haemoglobin.
In trials, 28 out of 29 sickle cell patients were free of severe pain and 39 of 42 beta thalassemia patients no longer needed blood transfusions for at least a year. It's hoped it could be a permanent fix.
Trials are continuing in the UK, US, France, Germany and Italy.
Around 15,000 people in the UK have sickle cell disorder, most with an African or Caribbean family background. More Than 1,000 people in the UK are affected by thalassemia, mainly those of Mediterranean, southeast Asian and Middle Eastern origin.
" Both sickle cell disease and beta thalassemia are painful, Life -long conditions That in some cases can be fatal, " said Julian Beach, interim Executive Director of healthcare quality and access at the Medicines and Healthcare products Regulatory Agency (MHRA).
" To date, a bone marrow transplant - which must come from a closely matched donor and carries a risk of Rejection - has been the only permanent treatment option. "
But now a " first-of-its-kind" gene-editing treatment called Casgevy has been authorised by the MHRA, He Said .
In trials, it has been " found to restore healthy haemoglobin production in the majority of participants with sickle-cell disease and transfusion-dependent beta thalassaemia, relieving the symptoms of disease" He Said .
John James OBE, Chief Executive of the Sickle Cell Society said: " Sickle cell disorder is an incredibly debilitating condition, causing significant pain for The People who live it and potentially leading to early mortality.
" There are limited medicines currently available to patients, so I welcome today's news That a new treatment has been judged safe and effective, which has the potential to significantly improve the quality of Life for so many. "
No price has yet been set for Casgevy, but The One off treatment might cost £1 million or More - which could be deemed too high a price for the NHS to bear.
In April, a US Think Tank , ICER,
For Casgevy, the drug is a personalised one-off treatment made from tweaking the patient's own cells - That makes it expensive and time-consuming. Add in the cost of research and development - There are just two labs one in the US and The Other in the UK - currently producing the drug.
The Boston-based pharma company involved, Vertex, will want its product used as widely as possible so will need to set a price That health services here and abroad are prepared to pay.
Related TopicsSource of news: bbc.com
