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Knock Out Transformers

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Initial release October 15, 2010
Directors Mani Shankar
Box office622. 3 million INR (US$8. 7 million)
Budget300 million INR
Release date15 October 2010
Played by Daran Norris
Date of Reg.
Date of Upd.
ID2394527
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About Knock Out Transformers


Knock Out is a medical officer and former member of the Decepticons. Originally, Knock Out was relocated to Earth after being summoned by Starscream to aid the damaged Megatron. Knock Out soon made a rival in the Autobot scout Bumblebee.

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... " In 2023, whether he s helping his kids on the monkey bars or training to Knock Out a nemesis, Tyson is as complex as he is charismatic - just the way we ve always liked our heroes...

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... The candidates might have calculated that it is profitable to make friends than to try to Knock Out opponents entirely...

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Male contraceptive pill prototype stops sperm swimming

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Feb 14,2023 12:11 pm

... Scientists say that is one of the advantages of the approach they are exploring - it will not Knock Out testosterone and cause any male hormone deficiency side effects...

Male contraceptive pill prototype stops sperm swimming

Jul 12,2022 12:10 am

By Michelle RobertsDigital health editor

An on-demand, non-hormonal male contraceptive pill may be a real possibility say scientists who have found a cell pathway, or switch, that stops sperm from being able to Swim .

suggest it keeps sperm stunned for at least a few Hours - Long enough to stop them reaching The Egg .

Many more tests are planned and needed, moving to rabbits before people.

The idea is users could pop a pill an hour before sex and keep an eye on The Clock for when it wears off.

How does it work?

Unlike The Female contraceptive pill, it does not involve any hormones.

Scientists say that is one of the advantages of the approach they are Exploring - it will not Knock Out testosterone and cause any male hormone deficiency Side Effects .

Instead, the " sperm-Swim " switch they are targeting is a cellular signalling protein called soluble Adenylyl Cyclase or sAC. The experimental male pill inhibits or blocks sAC.

In the early study in mice, funded by the US National Institutes of Health and published in the journal, a single dose of the drug, called TDI-11861, immobilised sperm before, during and after mating.

The effect lasted for around Three Hours . By 24 Hours , it appeared to have fully worn off.

One of The Scientists , Dr Melanie Balbach from Weill Cornell Medicine in New York , said it showed promise as a reversible, easy-to-use contraceptive.

If it does ultimately work in humans, men might be able to take it only when, and as often, As Needed . They could make day-to-day decisions about their fertility.

But it would not protect against sexually transmitted infections, experts warn. Condoms would be needed for that.

Prof Allan Pacey, professor of andrology at the University of Sheffield, said: " There is a pressing need for an effective, reversible, oral contraceptive for men and although many different approaches have been tested over The Years , none has yet reached The Market .

" The approach described here, to Knock Out key enzyme in sperm that is critical for sperm movement, is a really novel idea. The fact that it is able to act, and be reversed, so quickly is really quite exciting.

" If the trials on mice can be replicated in humans with the same degree of efficacy, then this could well be the male contraceptive approach we have been looking for. "

Meanwhile, other researchers have been looking at a slightly different pathway to halt sperm swimming, by blocking a protein on The Surface of sperm.

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Source of news: bbc.com

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