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Hans Clevers

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Gender Male
Age 67
Date of birth March 27,1957
Zodiac sign Aries
Born Eindhoven
Netherlands
SpouseEefke Petersen
Field Molecular genetics
BooksStem Cells: Scientific Facts and Fiction
Job Physician
Professor
Geneticist
Awards Breakthrough Prize in Life Sciences
Spinoza Prize
Dr A. H. Heineken Prize for Medicine
Official site hubrecht.eu
AffiliationsHubrecht Institute
Education Utrecht University
InterestsWnt
Intestine
Organoid
Adult Stem Cell
H index 236
Academic advisorRudy Ballieux
Date of Reg.
Date of Upd.
ID575460
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Hans Clevers Life story


Johannes Carolus Clevers is a Dutch molecular geneticist, cell biologist and stem cell researcher. He became the Head of Pharma, Research and Early Development, and a member of the Corporate Executive Committee, of the Swiss healthcare company Roche in 2022.

E. coli intestinal infection associated with colon cancer

Feb 27,2020 7:59 pm

A common type of intestinal bacteria can be published to increase a person's chance of developing bowel cancer, according to a study published in the journal.

The bacterium is a type of E. coli infection, the believe in up to One in five people, the scientists.

There is a toxin, experts say, can damage the cells that line the intestine, turn, potentially, some of the cells, the cancer cells in the course of time.

There are around 42 ' 000 new cases of colorectal cancer per year in the UK.

the experts still don't know how many of these can be linked to the E. coli strain, which makes the toxin colibactin.

How dangerous could it be?

The researchers suggest it may contribute to a minority of colorectal cancer cases - One in 20, or five out of 100 , But more research is needed to confirm The Link .

It is not a routine test for the bacterium, and it is not yet clear that people in the increased risk.

In some people it can live in the intestine and cause no Problem.

It is not The First infection associated with cancer, But . HPV is a virus, cervical cancer, and H pylori infection is associated with gastric cancer.

Is it the same as food poisoning?

no. This particular E. coli strain, is not One of those, connected with food poisoning.

There are many different types of E. coli. Many are part of normal intestinal Flora - the trillions of bacteria that naturally live in the intestines.

What has the study?

The Team from The Netherlands, the United Kingdom and the United States, used miniature replicas of the human intestine grown in the laboratory in order to test the effects of the toxin on cells.

she saw then compared the damage with More Than 5,000 colorectal cancer samples from patients and found an identical pattern or fingerprint of DNA damage in approximately 5% of The Samples .

What are colon cancer symptoms?

Most People with these symptoms do not have bowel cancer, But the NHS advice is to see your GP, if you have One or more of the symptoms, and she remained for More Than four weeks.

source:

the results help us?

experts say that it may be possible to develop a sensitive test for the early detection of colorectal tumors by using this knowledge about the toxin.

The findings may also offer a way to prevent some of the bowel cancer get rid of by the bacterium from The Body before they cause harm, with existing antibiotics.

One of the researchers, Professor Hans Clevers , from the Hubrecht Institute in The Netherlands, said: "Common antibiotics to kill the bacteria.

"this is The First Time we have seen a distinctive pattern of DNA damage in the colon cancer, which was caused by a bacterium that lives in our intestines. "

He said it to other intestinal bacteria, which do the same thing it can be.

Probiotic treatments, which represent a similar strain of E. coli called Nissle 1917, may also be a danger, perhaps, he added, But these are not the same, which is sold in yoghurt drinks in supermarkets.

"Although it may sound scary, there are still a lot left to understand about our how our gut bacteria affect our health, what we could do, and how much influence it has on colorectal cancer risk," says Nicola Smith , senior health information Manager at Cancer Research UK, who funded The Work . to know

"In The Future , what is The Role of bacteria in our gut play change the way we detect and prevent colon cancer may.

"But we know that around half of all colorectal cancer cases can be prevented by not Smoking, keeping a healthy weight and a balanced diet - so there are many changes you can make right now to reduce added risk," she said.

Genevieve Edwards, chief executive at bowel cancer UK, said: "Although this research is at an early stage, it adds to the growing body of evidence about The Role that bacteria and other microorganisms live in our intestines play in colorectal cancer development. "



cancer, infection, bowel cancer, medical research

Source of news: bbc.com

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