Blood Transfusion
| Use attributes for filter ! | |
| ICD-9-CM | 99. 0 |
|---|---|
| MedlinePlus | 000431 |
| Music groups | Intravenous therapy |
| Anemia | |
| Date of Reg. | |
| Date of Upd. | |
| ID | 2479575 |
About Blood Transfusion
Blood transfusion is the process of transferring blood or blood products into one's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood.
Infected blood: Tory rebellion expected on payouts amendment
... More than 3,000 people died after contracting HIV or hepatitis C after receiving a Blood Transfusion on the NHS or a treatment made from contaminated blood products...
Why Naga Munchetty is asking: ‘How are your periods?'
... " We see people coming in needing a Blood Transfusion because of their periods and to me we should never be getting to that stage...
Casgevy: UK approves gene-editing drug for blood disorders
... Patients with beta thalassemia often need a Blood Transfusion every few weeks of their lives...
Mark Dickey: US explorer freed from one of Turkey's deepest caves
... His condition improved after he was given a Blood Transfusion...
Mark Dickey: US man trapped in Turkey cave nears surface
... His condition later improved after he was given a Blood Transfusion...
Ukraine war: Russia hits blood transfusion centre, says Zelensky
...By Jaroslav LukivBBC NewsA Russian guided air bomb has hit a Blood Transfusion centre in north-eastern Ukraine, killing and injuring people, Ukraine s president has said...
Infected Blood Inquiry: Rishi Sunak to give evidence
... Thousands of NHS patients with haemophilia and other blood disorders became seriously ill after being given a Blood Transfusion or a new treatment called factor VIII or IX from the mid-1970s onwards...
East Kent NHS criticised over new mother herpes deaths
... Scrubbed and glovedThe inquest has heard how Ms Sampson needed a Blood Transfusion because of injuries sustained during the operation...
Casgevy: UK approves gene-editing drug for blood disorders
By Fergus WalshMedical editor
In a world first, medical regulators in the UK have approved a gene therapy That aims to cure two blood disorders.
The Treatment for sickle cell disease and beta thalassemia is The First to be licensed using the gene-editing tool known as Crispr, for which its
This is a revolutionary advance for two inherited blood conditions, both triggered by errors in the gene for haemoglobin.
People with sickle cell disease produce unusually shaped Red Blood cells That can cause problems because they do not live as long as healthy blood cells and can block blood vessels, causing pain and Life -threatening infections.
People with beta thalassaemia do not produce enough haemoglobin, which is used by Red Blood cells to carry oxygen around The Body . Patients with beta thalassemia often need a Blood Transfusion every few weeks of their lives.
How it works
DNA is The Blueprint of Life - and genes contain the instructions for how every cell in Our Body works.
Gene-editing allows the precise manipulation of DNA. The Treatment involves removing stem cells from a patient's bone marrow.
In a laboratory, the gene-editing tool Crispr uses molecular scissors to make precise cuts in the DNA of the cells, thus disabling the faulty gene. The modified cells are infused back, allowing The Body to start producing functioning haemoglobin.
In trials, 28 out of 29 sickle cell patients were free of severe pain and 39 of 42 beta thalassemia patients no longer needed blood transfusions for at least a year. It's hoped it could be a permanent fix.
Trials are continuing in the UK, US, France, Germany and Italy.
Around 15,000 people in the UK have sickle cell disorder, most with an African or Caribbean family background. More Than 1,000 people in the UK are affected by thalassemia, mainly those of Mediterranean, southeast Asian and Middle Eastern origin.
" Both sickle cell disease and beta thalassemia are painful, Life -long conditions That in some cases can be fatal, " said Julian Beach, interim Executive Director of healthcare quality and access at the Medicines and Healthcare products Regulatory Agency (MHRA).
" To date, a bone marrow transplant - which must come from a closely matched donor and carries a risk of Rejection - has been the only permanent treatment option. "
But now a " first-of-its-kind" gene-editing treatment called Casgevy has been authorised by the MHRA, He Said .
In trials, it has been " found to restore healthy haemoglobin production in the majority of participants with sickle-cell disease and transfusion-dependent beta thalassaemia, relieving the symptoms of disease" He Said .
John James OBE, Chief Executive of the Sickle Cell Society said: " Sickle cell disorder is an incredibly debilitating condition, causing significant pain for The People who live it and potentially leading to early mortality.
" There are limited medicines currently available to patients, so I welcome today's news That a new treatment has been judged safe and effective, which has the potential to significantly improve the quality of Life for so many. "
No price has yet been set for Casgevy, but The One off treatment might cost £1 million or More - which could be deemed too high a price for the NHS to bear.
In April, a US Think Tank , ICER,
For Casgevy, the drug is a personalised one-off treatment made from tweaking the patient's own cells - That makes it expensive and time-consuming. Add in the cost of research and development - There are just two labs one in the US and The Other in the UK - currently producing the drug.
The Boston-based pharma company involved, Vertex, will want its product used as widely as possible so will need to set a price That health services here and abroad are prepared to pay.
Related TopicsSource of news: bbc.com
