Ms Huffman is accused of paying $15,000 (£11,500) to have her daughter's exam answers covertly corrected in 2017.
The 56-year-old is one of 14 people set to plead guilty among the 50 charged, who include college athletic coaches.
As part of her plea deal, prosecutors are recommending a prison term of four to 10 months. She has also agreed to pay a $20,000 fine.
In a statement, She Said : "I Am in full acceptance of my guilt, and with deep regret and shame over what I have done, I accept full responsibility for my actions and will accept the consequences that stem from those actions.
"I want to apologise to them and, especially, I want to apologise to The Students who work hard Every Day to get into college, and to their parents who make tremendous sacrifices to support their children and do so honestly. "
She added in The Statement that her daughter had known nothing about her actions: "In my misguided and profoundly wrong way, I have betrayed her. This transgression toward her and The Public , I will carry for the rest of My Life . "What are the accusations?
The case relates to the period between 2011 and 2018, when investigators say parents tried to cheat the usual US admission process.
They say parents paid bribes, had exams altered and even had their children edited on to stock photos to pretend they played sports.
Ms Loughlin is accused along with her husband of paying nearly $500,000 in bribes to get their two daughters admitted to the University of Southern California .
They are not among those who have agreed to plead guilty and have not publicly addressed the allegations, the Associated Press (AP) news agency reports.
Investigators say they helped them Get In on rowing scholarships, even though neither student had actually participated in the sport.
She has agreed to plead guilty to a charge of conspiracy to commit mail fraud and honest services mail fraud, AP reports.