About Old Age
Old age refers to ages nearing or surpassing the life expectancy of human beings, and is thus the end of the human life cycle. Terms and euphemisms include old people, the elderly, seniors, senior citizens, older adults, and the elders.
My pre-death grief over husband's dementia
... " Pre-death grief is really about the loss of the person before their actual death, " said Dr Adam Daly, chair of HIS guideline development group and a consultant in Old Age psychiatry...
Bobi, the world's oldest dog ever, dies aged 31
... Bobi s grand Old Age was validated by the Portuguese government s pet database, which is managed by the National Union of Veterinarians...
Michael Caine confirms retirement from acting after The Great Escaper
... But Sir Michael said the likelihood of fewer parts being offered to him in Old Age has ultimately prompted his decision to retire...
Businessman Mohamed Al Fayed dies aged 94
... In a statement released tonight, his family said: " Mrs Mohamed Al Fayed, her children and grandchildren wish to confirm that her beloved husband, their father and their grandfather, Mohamed, has passed away peacefully of Old Age on Wednesday August 30, 2023...
School concrete crisis: Your questions answered
... Many buildings from the 60s and 70s built from many materials are now having problems due to inadequate maintenance, and Old Age...
Rescue dogs: Oldest Dogs Trust rescue marks anniversary
... Ms Mogford said: " When we re looking for homes for dogs like that, it s [about considering] where the dog s going to be sleeping, do they need to go up and down stairs a lot? If they do have medical conditions, can they afford that? " There s a variety of things that come with Old Age...
Heatwave: How hot is too hot for the human body?
... " You re going to leave the lab today with a smile on your face - all of these statistics coming are telling me that you have risen to the challenge and you ve done a jolly good job, " says Prof BaileyBut Old Age, heart disease, lung disease, dementia and some medications mean the body is already working harder to keep going, and is less able to respond to the heat...
Fiona Phillips: How common is early Alzheimer's?
... Do many younger people get Alzheimer s? Alzheimer s is mostly a disease of Old Age - one in six people over the age of 80 develop it...
Mutations across species reveal clues to ageing
How long animals live is linked to how quickly their genetic code mutates, a study suggests.
Researchers discovered that Mammals - from tigers to Humans - have roughly the same number of mutations by The Time they die of Old Age .
But short-lived animals tend to burn through their allowance more rapidly, the analysis of 16 species indicates.
The researchers say it helps explain why we age and sheds light on one of cancer's most perplexing mysteries.
Experts said the findings, by researchers at the Wellcome Sanger Institute, were " staggering" and " thought-provoking".
Mutations are changes that creep into the instruction manual for building and running our Bodies - our DNA.
Those mutations have long been known to be at the root of cancer, but whether they were important for ageing has been debated for decades. Researchers at Wellcome say they have produced " The First experimental evidence" suggesting they are.
They analysed how quickly mutations occur in species with different life expectancies. They looked at DNA from a cat, black and white colobus, dog, ferret, giraffe, horse, human, lion, mouse, naked mole rat, rabbit, rat, ring-tailed lemur and a tiger.
The study, showed mice rattle through nearly 800 mutations a year during their short lives, which last just under Four Years .
And the longer animals live, the fewer mutations they Pick Up each year.
Dogs have around 249 annual mutations, a lion 160 and a giraffe 99. Humans averaged 47.
One of the researchers, Dr Alex Cagan, said The Pattern was " striking" and it was " really surprising and exciting" that all The Animals in the study converged on " about 3,200" mutations across their lifetime.
If people's DNA mutated at the same rate as that of mice, we would die with More Than 50,000 genetic alterations.
" Despite having different lifespans, at The End of life The Mammals had the same number of mutations, " Dr Cagan told The Bbc .
" This is The Number , but what does it mean? It's a mystery to us, " He Said .
It could be the cells in The Body reach a critical number of mutations And Then conk out. There are also ideas that " a few [cells] behaving badly" start to take over critical tissue, such as in The Heart , as we age, so organs do not function properly.
Ageing, however, is unlikely to be down to a single process inside our Bodies ' cells.
and are also thought to play a role. However, if mutations are involved, then it poses the question whether there are ways of slowing the genetic damage or even repairing it.
The researchers want to see whether this pattern holds true for all life or just for Mammals . They are aiming to add fish to the analysis, including a Greenland Shark , which can and is the longest-living vertebrate in The World .
Cancer paradoxIn cancer science there is a conundrum known as " Peto's paradox" - why don't big, long-living animals have sky-high rates of cancer?
The more cells there are in your body and the longer you live, the greater the chance that one of them becomes cancerous. This should be terrible news for elephant and whales.
" Whales have trillions more cells [than us]. They shouldn't exist as they'd have cancer before adulthood, " says Dr Cagan.
Big Animals tend To Live longer, so their slower mutation rate could help explain the paradox, but the researchers say this is far from the whole story.
Naked mole rats and giraffes both live to broadly the same age, with similar mutation rates, despite giraffes being thousands of times larger.
" You'd expect The Giraffe 's mutation rate to be even lower, but it's like body size doesn't matter, " said Dr Cagan.
Instead, the researchers argue that other methods of suppressing cancer must have evolved - which could inspire new cancer therapies. For example, of a chunk of DNA that suppresses tumours.
Dr Alexander Gorelick and Dr Kamila Naxerova, from Harvard Medical School , said The Gulf between a human's 47 mutations a year and a mouse's 800 was huge.
" This difference is staggering, given the large overall similarities between human and mouse genomes.
" These results are thought-provoking. "
Dr Simon Spiro , a wildlife veterinary pathologist at the Zoological Society of London, said: " Animals often live much longer in zoos than they do in The Wild , so our vets' Time Is often spent dealing with conditions related to Old Age .
" The genetic changes identified in this study suggest that diseases of Old Age will be similar across a wide range of Mammals , whether Old Age begins at seven months or 70 years. "
Source of news: bbc.com